Short-term electrical stimulation enhances the effectiveness of Botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients
| Autor: | D. Luecke, K.H. Mauritz, Stefan Hesse, MT Jahnke |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Botulinum Toxins Electric Stimulation Therapy Hemiplegia Stimulation Walking Electromyography medicine.disease_cause Muscle tone medicine Humans Spasticity Aged Leg medicine.diagnostic_test Anti-Dyskinesia Agents business.industry General Neuroscience Middle Aged Combined Modality Therapy Botulinum toxin Surgery Cerebrovascular Disorders Hemiparesis medicine.anatomical_structure Muscle Spasticity Gait analysis Anesthesia Clostridium botulinum Female medicine.symptom business medicine.drug |
| Zdroj: | Neuroscience Letters. 201:37-40 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)12124-9 |
| Popis: | The study tested the spasmolytic effect of Botulinum toxin A in two groups of hemiparetic patients with lower limb spasticity: in the first group (n = 5) 2000 U Dysport were injected into the soleus, tibialis posterior and both heads of gastrocnemius muscles alone; the second (n = 5) received additional repetitive alternating electrical stimulation of M. tibialis anterior and plantar flexors for 30 min six times per day during the 3 days following the injection. Muscle tone, rated by the Ashworth spasticity score, and gait analysis including recording of vertical ground reaction forces, were assessed before and 4 weeks after injection. The combined treatment proved to be more effective with respect to the clinically assessed reduction of muscle tone, gait velocity, stride length, stance- and swing-symmetry (P < 0.05). The result is discussed with reference to animal experiments demonstrating enhanced toxin uptake and accelerated onset of its paralytic effect by electrical stimulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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