Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease
| Autor: | Shiek S. S. J. Ahmed, Ram Murugesan, Paramasivam Prabu, Dragan Milenkovic, K. G. Monisha, M. Chokkalingam |
|---|---|
| Přispěvatelé: | Chettinad Health City, New Mexico State University, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chettinad Academy Of Research And Education, Chettinad Academy of Research and Education (CARE) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male lcsh:Medicine Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Cardiovascular Coronary artery disease chemistry.chemical_compound 0302 clinical medicine Neurotrophic factors lcsh:Science système cardiovasculaire Subclinical infection Multidisciplinary Middle Aged Lipids Pathophysiology 3. Good health Heart Disease Echocardiography Cardiology cerveau Biomarker (medicine) Biomedical Imaging Female biomarqueur Adult medicine.medical_specialty Heart Ventricles 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Clinical Research Internal medicine medicine Humans cardiovascular diseases Heart Disease - Coronary Heart Disease Aged Brain-derived neurotrophic factor Creatinine business.industry Brain-Derived Neurotrophic Factor lcsh:R Case-control study medicine.disease Atherosclerosis 030104 developmental biology chemistry Case-Control Studies lcsh:Q business Biomarkers |
| Zdroj: | Scientific reports, vol 10, iss 1 Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.16359. ⟨10.1038/s41598-020-73296-6⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports, 2020, 10 (1), pp.16359. ⟨10.1038/s41598-020-73296-6⟩ |
| ISSN: | 2045-2322 |
| Popis: | Brain-derived neurotrophic factor (BDNF) plays a central pivotal role in the development of the cardiovascular system. Recent evidence suggests that BDNF has adverse subclinical cardiac remodeling in participants with cardiovascular disease risk factors. Relating serum BDNF levels with two-dimensional echocardiographic indices will provide insights into the BDNF mediated pathophysiology in coronary artery disease (CAD) that may shed light upon potential diagnostic biomarkers. For the study, 221 participants were recruited and classified based on coronary angiogram examination as control (n = 105) and CAD (n = 116). All participants underwent routine blood investigation, two-dimensional echocardiography, and serum BDNF estimation. As a result, total cholesterol, triglyceride, low-density lipid, high-density lipid, HbA1c (glycosylated hemoglobin), serum creatinine, eosinophils, lymphocyte, monocytes, neutrophils, and platelets were significantly elevated in CAD individuals compared to controls. Notably, the serum BDNF was significantly lower in individuals with CAD (30.69 ± 5.45 ng/ml) than controls (46.58 ± 7.95 ng/ml). Multivariate regression analysis showed neutrophils, total cholesterol, left ventricular mass index, mitral inflow E/A ratio, and pulmonary vein AR duration were associated with low BDNF in CAD. Four independent support vector machine (SVM) models performed to ensure the BDNF level in the classification of CAD from healthy controls. Particularly, the model with serum BDNF concentration and blood parameters of CAD achieved significant improvement from 90.95 to 98.19% in detecting CAD from healthy controls. Overall, our analysis provides a significant molecular linkage between the serum BDNF level and cardiovascular function. Our results contribute to the emerging evidence of BDNF as a potential diagnostic value in CAD that might lead to clinical application. |
| Databáze: | OpenAIRE |
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