Investigating T Cell Immunity in Cancer: Achievements and Prospects
| Autor: | Jazmina Gonzalez Cruz, Graham R. Leggatt, James W. Wells, Hui Yi Chew, Zhen Zeng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
T-Lymphocytes medicine.medical_treatment T cell CD8 T cells Review CD8-Positive T-Lymphocytes Biology cytotoxic T lymphocytes Catalysis Inorganic Chemistry lcsh:Chemistry Mice 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms Tumor Microenvironment T cell immunity medicine Animals Humans Cytotoxic T cell cancer Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy tumour antigen Organic Chemistry Cancer General Medicine Immunotherapy medicine.disease Computer Science Applications CAR CTL checkpoint inhibitor 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Cancer research immunotherapy CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 2907, p 2907 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | T cells play a key role in tumour surveillance, both identifying and eliminating transformed cells. However, as tumours become established they form their own suppressive microenvironments capable of shutting down T cell function, and allowing tumours to persist and grow. To further understand the tumour microenvironment, including the interplay between different immune cells and their role in anti-tumour immune responses, a number of studies from mouse models to clinical trials have been performed. In this review, we examine mechanisms utilized by tumour cells to reduce their visibility to CD8+ Cytotoxic T lymphocytes (CTL), as well as therapeutic strategies trialled to overcome these tumour-evasion mechanisms. Next, we summarize recent advances in approaches to enhance CAR T cell activity and persistence over the past 10 years, including bispecific CAR T cell design and early evidence of efficacy. Lastly, we examine mechanisms of T cell infiltration and tumour regression, and discuss the strengths and weaknesses of different strategies to investigate T cell function in murine tumour models. |
| Databáze: | OpenAIRE |
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