Paraneoplastic dermatomyositis and prostate cancer: Myopathy regression under cancer-directed therapy

Autor:	Luís Maduro, Marta Mesquita Pinto, Carolina Vasques, Ana Isabel Martins, Filipa Ferreira, Mafalda Miranda Baleiras
Rok vydání:	2021
Předmět:	Oncology medicine.medical_specialty Myositis- Specific Antibody business.industry Prostate Cancer Cancer Case Report Dermatology Dermatomyositis medicine.disease Prostate cancer Paraneoplastic Syndrome Recurrence Internal medicine RL1-803 medicine medicine.symptom business Myopathy
Zdroj:	Dermatology Reports (2021) Dermatology Reports
ISSN:	2036-7392
Popis:	Prostate cancer is the second most frequent malignancy in men worldwide and the fifth leading cause of death. Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by musculocutaneous manifestations. However, DM can also present as a paraneoplastic syndrome of an underlying neoplasm. We report a case of a 65-year-old man diagnosed with prostate adenocarcinoma in the setting of severe dysphagia, muscle weakness and a facial erythematous rash. At first, the DM-related symptoms resolved with the initial treatment for the underlying malignancy. Yet, they flared up as the tumor progressed. To sum up, DM is a rare systemic disorder with unknown etiology. There is a well-established association between DM and malignancy. Malignancy-headed therapy can improve DM manifestations and the recurrence of DM symptoms may act as an early warning of malignancy relapse.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86b9f3304cccd979db40f28f61ce26d https://pubmed.ncbi.nlm.nih.gov/34880970 Zobrazit plný text záznamu Plný text ve formátu PDF