Pneumonia initiates a tauopathy
| Autor: | Jean-Francois Pittet, Phoibe Renema, Mike T. Lin, Jessica Bell, Troy Stevens, Brant M. Wagener, Corey E. Ventetuolo, Ron Balczon, C Michael Francis, Chung-Sik Choi, Chun Zhou, Neel R. Sodha, S.B. Voth, Ji Young Lee, Anna Koloteva, Adeel Abbasi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Amyloid Long-Term Potentiation long‐term potentiation prion disease Hippocampus tau Proteins Hippocampal formation Biochemistry lung Mice Young Adult Alzheimer Disease mental disorders Genetics medicine Cytotoxic T cell Animals Humans Cognitive Dysfunction Molecular Biology Research Articles Aged Mice Knockout business.industry Long-term potentiation Pneumonia Middle Aged extracorporeal membrane oxygenation medicine.disease Rats Mice Inbred C57BL Disease Models Animal Tauopathies Knockout mouse Immunology Female Tauopathy business Biotechnology Research Article dementia |
| Zdroj: | The FASEB Journal |
| ISSN: | 1530-6860 |
| Popis: | Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment of long‐term potentiation; and, (3) inhibit long‐term potentiation dependent upon tau. Cytotoxic amyloid and tau species were recovered from the blood and the hippocampus following pneumonia, and they were present in the extracorporeal membrane oxygenation oxygenators of patients with pneumonia, especially in those who died. Introduction of immunopurified blood‐borne amyloid and tau into either the airways or the blood of uninfected animals acutely and chronically impaired hippocampal information processing. In contrast, the infection did not impair long‐term potentiation in tau knockout mice and the amyloid‐ and tau‐dependent disruption in hippocampal signaling was less severe in tau knockout mice. Moreover, the infection did not elicit cytotoxic amyloid and tau variants in tau knockout mice. Therefore, pneumonia initiates a tauopathy that contributes to cognitive dysfunction. |
| Databáze: | OpenAIRE |
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