KSHV genotypes A and C are more frequent in Kaposi sarcoma lesions from Brazilian patients with and without HIV infection, respectively
| Autor: | Maura M. Bacchi, Deilson Elgui de Oliveira, Ana Paula Ferraz da Silva, Suzane Ramos da Silva, Carlos E. Bacchi |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Adolescent Genotype Molecular Sequence Data Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Young Adult Biological property medicine Humans Base sequence In patient Young adult Sarcoma Kaposi Phylogeny Aged Aged 80 and over Base Sequence virus diseases Middle Aged medicine.disease Virology Oncology Herpesvirus 8 Human Immunology Female Sarcoma Viral genotype Brazil |
| Zdroj: | Cancer Letters. 301:85-94 |
| ISSN: | 0304-3835 |
| Popis: | The present study aimed to evaluate the frequency of KSHV genotypes isolated from Kaposi sarcoma (KS) lesions in patients from Brazil. Fifty KS cases were evaluated. The most frequently detected viral genotypes were A (50.0%) and C (48.0%); the B genotype was isolated only in one case (2.0%). Noteworthy, there was a significant predominance of A genotypes in KS lesions from HIV-positive patients, whereas C genotypes were found mostly in the HIV-negative setting. This finding supports the hypothesis that distinct KSHV genotypes have a non-random distribution in KS, which might be attributable to unique biological properties. |
| Databáze: | OpenAIRE |
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