Hydrogel of polysaccharide of sugarcane molasses as carrier of bone morphogenetic protein in the reconstruction of critical bone defects in rats
| Autor: | Sidcley Bernardino-Araújo, Martinho Dinoá Medeiros Júnior, José Lamartine de Andrade Aguiar, Elaine Judite de Amorim Carvalho, Ivson Souza Catunda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Bone Regeneration RD1-811 lcsh:Surgery Biocompatible Materials Calvaria Bone healing engineering.material Polysaccharide Bone morphogenetic protein Bone tissue Hydrogel Polyethylene Glycol Dimethacrylate Andrology Biopolymers Polysaccharides medicine Animals Bone regeneration chemistry.chemical_classification Drug Carriers Bone Transplantation Reproducibility of Results lcsh:RD1-811 Controlled release Saccharum Surgery Rats Treatment Outcome medicine.anatomical_structure chemistry Bone Substitutes Bone Morphogenetic Proteins engineering Biopolymer |
| Zdroj: | Acta Cirurgica Brasileira, Vol 28, Iss 4, Pp 233-238 (2013) Acta Cirurgica Brasileira, Volume: 28, Issue: 4, Pages: 233-238, Published: APR 2013 Acta Cirúrgica Brasileira v.28 n.4 2013 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 1678-2674 0102-8650 |
| Popis: | PURPOSE: To evaluate the benefit of using carriers such as the biopolymer gel (hidrogel of polysaccharide of sugarcane molasses) associated with the bone morphogenetic proteins (BMP's) in the repair of critical bone defects in calvaria of Wistar rats. METHODS: Forty-two rats were submitted to a surgical calvaria bone defects. These animals were divided into two experimental groups, positive control group and negative control group. The Group I the calvaria defect was filled up with biopolymer gel, biological membrane, BMP and lyophilized graft. The Group II was treated with biopolymer gel, BMP and lyophilized graft. And the group III (positive control group) was treated with BMP, lyophilized graft and biological membrane. In the negative control group (Group IV) a defect was made in the rat calvaria and the animals were sacrificed immediately after the surgery. The animals of experimental groups and positive control group were slaughtered after subsequent periods of 90 and 180 days. In these periods, the histological analysis and image assessment by cone bean tomographic imaging were obtained. RESULTS: There was highest bone tissue formation with statistically significant results in the groups that associated biopolymer gel and membrane (Group I), followed by the group III (BMP, lyophilized graft and biological membrane). The lower bone formation occurred in the group not using the sugarcane biopolymer gel (Group II). The radiolucent areas of the analyzes of 180 days among the groups studied were respectively, 14.98 mm², 26.65 mm² and 35.81 mm². CONCLUSION: The biopolymer gel showed to be an excellent bone morphogenetic protein carrier, probably by facilitating the controlled release of these proteins in the process of bone repair. |
| Databáze: | OpenAIRE |
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