Treatment with l-DOPA in early life restored pituitary-adrenocortical response to emotional stress in adult rats with inherited arterial hypertension
| Autor: | Maslova Ln, A. L. Markel, Naumenko Ev |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Ontogeny Emotions Pituitary-Adrenal System Adrenergic Blood Pressure Levodopa Norepinephrine chemistry.chemical_compound Corticosterone Dopamine Internal medicine Animals Medicine Molecular Biology business.industry General Neuroscience Rats Inbred Strains Azepines Emotional stress Dihydroxyphenylalanine Early life Rats Endocrinology Blood pressure chemistry Hypertension Neurology (clinical) business Stress Psychological Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 546:55-60 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(91)91158-w |
| Popis: | This study investigates the function of the hypothalamic-pituitary-adrenocortical system (HPAS) in adult rats with inherited stress-induced arterial hypertension (ISIAH rats) whose arterial blood pressure was lowered by the dopamine precursor l -DOPA treatment during early development (on days 21–25 of life). The response of the HPAS induced by emotional stress was significantly lower in intact ISIAH rats than in normotensive Wistar animals. Injections of l -DOPA on days 21–23 or 21–25 of postnatal life were followed by a long-lasting complete restoration of the emotional stress response in adult ISIAH rats. The restoring effect of l -DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline and did not relate to an increase of the plasma corticosterone level after l -DOPA administration in early ontogeny. |
| Databáze: | OpenAIRE |
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