Adenocarcinoma of the Body and Tail of the Pancreas: Is There Room for Adjuvant Radiotherapy?
| Autor: | Pascale Romestaing, Régis Coquard, Jean-Pierre Gerard, Jean-Michel Ardiet, L. Ayzac, Irénée Sentenac, F. N. Gilly, Georges Braillon |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Malignancy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Treatment Failure Stage (cooking) Aged Neoplasm Staging Retrospective Studies Chemotherapy business.industry General surgery Retrospective cohort study General Medicine Middle Aged medicine.disease Survival Analysis Surgery Pancreatic Neoplasms medicine.anatomical_structure Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Fluorouracil business Pancreas Progressive disease |
| Zdroj: | Tumori Journal. 83:740-742 |
| ISSN: | 2038-2529 0300-8916 |
| Popis: | Aims and background Adenocarcinoma of the body and tail of the pancreas is a rare malignancy with a poor prognosis. Few long-term survivors have been reported in the literature. The role of adjuvant treatment after curative resection has not yet been assessed. This retrospective study aims to describe the patterns of failure and the survival of 10 patients treated with resection and adjuvant radiotherapy. Materials and methods from 1982 to June 1994, 10 patients with adenocarcinoma of the body and tail of the pancreas received adjuvant radiotherapy in our department. There were 4 females and 6 males, with a median age of 63 years (range, 45–77). The pT distribution was 2 pT1, 4 pT2, 4 pT3 and for pN it was 7 pN0 and 3 pN1. Four patients had stage I, 3 stage II and 3 stage III disease. All the patients underwent a resection: distal pancreatectomy in 7, partial resection of the body in 1, and total pancreatectomy in 2. Gross residual disease was present in 2 cases. Three patients received intraoperative radiotherapy up to a dose of 12–15 Gy. Postoperative radiotherapy was given in 9 patients with a dose ranging from 40 to 50 Gy (median, 45). One patient who received intraoperative radiotherapy had no postoperative radiotherapy. In 4 patients, chemotherapy with 5-fluorouracil was given during the first week of irradiation. Results Six patients experienced a local-regional relapse and 3 developed metastases. The median survival was 21 months. The 5-year overall survival was 15%. Eight patients died of progressive disease. One patient who presented with stage I disease was alive and free of disease at 24 months from diagnosis and, interestingly, one with stage III disease was alive at 111 months. No severe treatment-related complications were observed. Conclusions As in carcinoma of the head of the pancreas, adjuvant radiotherapy should be considered as an adjuvant treatment of resected adenocarcinoma of the body and tail of the pancreas. Further evaluation is necessary to assess the role of intraoperative radiotherapy. |
| Databáze: | OpenAIRE |
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