Importance of morphological changes in T-U waves during bepridil therapy as a predictor of ventricular arrhythmic event
| Autor: | Shoko Ishikawa, Masahiko Moriguchi, Hiroe Niwano, Tomoko Kosukegawa, Yoshihiro Yumoto, Masami Murakami, Shinichi Niwano, Michiro Kiryu, Sayaka Kurokawa, Tohru Izumi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Bepridil Torsades de pointes QT interval Electrocardiography Torsades de Pointes Internal medicine Atrial Fibrillation Medicine Humans Aged Univariate analysis medicine.diagnostic_test business.industry Atrial fibrillation General Medicine Odds ratio Middle Aged medicine.disease Anesthesia Cardiology Population study Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug Follow-Up Studies |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 74(5) |
| ISSN: | 1347-4820 |
| Popis: | Background: Although bepridil is a useful anti-arrhythmic agent for atrial fibrillation, the appearance of serious ventricular arrhythmia, such as torsades de pointes, might be a problem. In this study, T-U wave morphology was evaluated during bepridil therapy and was examined as a predictor of ventricular arrhythmic events. Methods and Results: The study population consisted of 113 patients on bepridil therapy. They were divided into 2 groups with and without ventricular arrhythmic events. Morphological changes in T-U waves were analyzed in leads V2-5. During bepridil treatment, the QTc interval was prolonged from 0.45±0.01 to 0.49±0.01 s1/2 in all patients (P |
| Databáze: | OpenAIRE |
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