Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia

Autor: Abebe Hordofa, Tirhas Niguse, Mintesnot Aragaw Mamo, Asegdew Atlaw, Abebe Edao Negeso, Yakob Gebregziabher Tsegay, Shambel Araya, Mahlet Cheru, Aschalew Aytenew, Zemenu Tamir, Moges Wordofa
Rok vydání: 2021
Předmět:
Viral Diseases
Physiology
Cross-sectional study
Cardiovascular Medicine
030204 cardiovascular system & hematology
Severity of Illness Index
Biochemistry
Geographical Locations
Medical Conditions
0302 clinical medicine
Risk Factors
Coagulopathy
Animal Cells
Medicine and Health Sciences
Prospective Studies
Child
Prospective cohort study
Aged
80 and over
Multidisciplinary
medicine.diagnostic_test
Age Factors
Hematology
Proteases
Middle Aged
Prognosis
Thrombosis
Enzymes
Body Fluids
Hospitalization
Infectious Diseases
Blood
Coagulation
Cardiovascular Diseases
Child
Preschool
030220 oncology & carcinogenesis
Medicine
Partial Thromboplastin Time
Anatomy
Cellular Types
circulatory and respiratory physiology
Research Article
Partial thromboplastin time
Adult
Platelets
medicine.medical_specialty
Adolescent
Critical Illness
Science
Cardiology
Young Adult
03 medical and health sciences
Sex Factors
Diagnostic Medicine
Internal medicine
Severity of illness
medicine
Humans
International Normalized Ratio
Blood Coagulation
Aged
SARS
Prothrombin time
Blood Cells
Coagulation Disorders
Platelet Count
SARS-CoV-2
business.industry
COVID-19
Biology and Life Sciences
Proteins
Covid 19
Cell Biology
medicine.disease
Thrombocytopenia
Cross-Sectional Studies
People and Places
Africa
Prothrombin Time
Enzymology
Ethiopia
Serine Proteases
business
Zdroj: PLoS ONE, Vol 16, Iss 6, p e0252939 (2021)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0252939
Popis: Background Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. Methods This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p Result A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. Conclusion In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.
Databáze: OpenAIRE
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