A Multimodal Biomicroscopic System based on High-frequency AcousticRadiation Force Impulse and Multispectral Imaging Techniques for TumorCharacterization Ex vivo
| Autor: | Eunjoo Kim, Jihun Kim, Jun-Young Kim, Anna Seo, Sung Hyouk Choi, Hyung Jin Yoon, Jae Youn Hwang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tumor resection Multispectral image Microscopy Acoustic lcsh:Medicine Cancer recurrence Multimodal Imaging Article Metastasis 03 medical and health sciences Neoplasms Medicine Humans lcsh:Science Acoustic radiation force Colorectal Tumors Multidisciplinary business.industry Phantoms Imaging lcsh:R Ultrasound Equipment Design medicine.disease Biomechanical Phenomena 030104 developmental biology lcsh:Q Radiology business Ex vivo |
| Zdroj: | SCIENTIFIC REPORTS(7) Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| Popis: | We report a multimodal biomicroscopic system which offers high-frequency ultrasound B-mode, acoustic radiation force impulse (ARFI), and multispectral imaging for qualitative tumor characterization ex vivo. Examinations of resected tissues from diseased regions such as tumors are crucial procedures during surgical operations to treat cancer. Particularly, if tiny tumors remain at surgical sites after tumor resection, such tumors can result in unwanted outcomes, such as cancer recurrence or metastasis to other organs. To avoid this, accurate characterizations of tumors resected during surgery are necessary. To this end, we devised a multimodal biomicroscopic system including high-frequency ultrasound B-mode, ARFI, and multispectral imaging modalities to examine resected tumors with high levels of accuracy. This system was evaluated with tissue-mimicking phantoms with different mechanical properties. In addition, colorectal tumors excised from cancer patients were examined. The proposed system offers highly resolved anatomical, mechanical, chemical information pertaining to tumors, thus allowing the detection of tumor regions from the surface to deep inside tissues. These results therefore suggest that the multimodal biomicroscopic system has the potential to undertake qualitative characterizations of excised tumors ex vivo. |
| Databáze: | OpenAIRE |
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