Impact of varicocelectomy on urine dopamine value in patients with premature ejaculation and varicocele

Autor:	Seyed Reza Hosseini, Mohammad Mohseni, Farshid Alizadeh
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Time Factors Urology Dopamine Varicocele 030232 urology & nephrology 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Endocrinology Premature ejaculation Testis medicine Humans In patient Ejaculation Prospective Studies Premature Ejaculation Prospective cohort study Creatinine 030219 obstetrics & reproductive medicine business.industry General Medicine Urine dopamine medicine.disease Treatment Outcome chemistry Intravaginal ejaculation latency time medicine.symptom business Vascular Surgical Procedures medicine.drug
Zdroj:	AndrologiaREFERENCES. 51(10)
ISSN:	1439-0272
Popis:	Dopamine is an important regulator of male sexual function and behaviour. Decreased levels of this substance have been observed in blood and seminal plasma of infertile men. Hence, this study was carried out to determine the impact of varicocelectomy on 24-hr urine dopamine values in patients with both premature ejaculation (PE) and varicocele. In this prospective study, 55 consecutive patients with premature ejaculation and grade 2 or 3 varicocele were enrolled. The urine dopamine level was measured in a 24-hr sample by HPLC method in a single laboratory centre. Two samples were gathered from each patient, one before and the other 1 month after varicocelectomy. The mean initial and final 24-hr urine dopamine levels were 259.6 ± 86.3 and 602.9 ± 88.4 micrograms, respectively, showing statistically significant increase (p = .0001), while there was no statistically significant difference between urine volume and creatinine. However, the change in intravaginal ejaculation latency time value was not statistically significant at this short time visit. According to our findings, varicocelectomy results in a significant increase in 24-hr urine dopamine levels in patients with premature ejaculation and varicocele. However, the effect of this change on premature ejaculation in the long term has yet to be determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85bf1a0ca2a8059a17e646c9462b93d https://pubmed.ncbi.nlm.nih.gov/31468556 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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