Stability, bactericidal activity, vitamin B6 activity and gastrointestinal absorption of benzoic acid esters of pyridoxine
| Autor: | Nobuyasu Mizuno, Emiko Morita, Miyako Fukumoto-Hato, Miyuki Matsumoto-Yoshino |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Pyridoxic Acid Metabolite Medicine (miscellaneous) Bacillus subtilis Benzoates Absorption Mice Hydrolysis chemistry.chemical_compound Drug Stability Digestive System Physiological Phenomena Seizures Oral administration Escherichia coli Acetone medicine Animals Humans Benzoic acid Nutrition and Dietetics Chromatography biology Chemistry Pyridoxine Benzoic Acid biology.organism_classification Anti-Bacterial Agents Rats Biochemistry medicine.drug |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 27:165-175 |
| ISSN: | 1881-7742 0301-4800 |
| Popis: | alpha 4-O-Benzoyl-pyridoxine (PN-4'MB) and alpha 5-O-benzoyl-pyridoxine (PN-5'MB) were hydrolyzed in 10% aqueous solution of acetone at pH 1-4. They were hydrolyzed obeying apparent first-order kinetics. In the pH range of 1-7, PN-4'MB was hydrolyzed 10 times faster than PN-5'-MB. At pH 7-12, an interconversion between the two derivatives was observed. They were bactericidal against Escherichia coli and Bacillus subtilis and prevented severe convulsions induced in mouse by 4'-methoxypyridoxine, a potent antagonist of vitamin B6. PN-4'MB was hydrolyzed with the homogenate of rat liver more easily than PN-5'MB. The metabolite of PN-MBs in man was identified as 4'-pyridoxic acid, i.e., a principal metabolite of PN, using high-performance liquid chromatography. The amount of urinary excretion of 4'-pyridoxic acid in 10 hr after oral administration of PN-4'MB or PN-5'MB was as large as that of PN. |
| Databáze: | OpenAIRE |
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