Detection of left anterior descending coronary artery disease in patients with left bundle branch block
| Autor: | A. Cahid Civelek, Henry N. Wagner, Jonathan M. Links, K. Durski, Edwaldo E. Camargo, Jeffrey A. Brinker, John T. Flaherty, Ibrahim Gozukara, Mehmet A. Ozguven |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Heart block Bundle-Branch Block Coronary Disease Anterior Descending Coronary Artery Chest pain Coronary Angiography Sensitivity and Specificity Coronary artery disease Electrocardiography Spect imaging Internal medicine medicine Image Processing Computer-Assisted Humans cardiovascular diseases Aged Tomography Emission-Computed Single-Photon Bundle branch block Left bundle branch block business.industry Middle Aged medicine.disease Stenosis Thallium Radioisotopes cardiovascular system Cardiology Exercise Test Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 70(20) |
| ISSN: | 0002-9149 |
| Popis: | The detection of coronary artery disease is difficult if a patient has electrocardiographic evidence of left bundle branch block (BBB). Septal blood flow may be reduced in patients with left BBB, despite no angiographic evidence of left anterior descending (LAD) coronary artery disease. We have developed a new method of quantification of Thallium-201 single-photon emission computed tomographic (SPECT) images with the aim of better separating patients with left BBB and LAD disease from those with left BBB alone. The study cohort comprised 8 normal subjects (group I) and 20 patients with left BBB and chest pain who underwent thallium-201 SPECT imaging and coronary angiography. Eight patients (group II) hador = 50% LAD stenosis, and 12 (group III) hador = 70% LAD stenosis. Septal abnormality scores on the second short-axis slice from the base were computed, based on comparison of each subject's short-axis circumferential profile with a normal reference curve. This followed a procedure in which each profile was scaled to minimize differences in its absolute level in relation to the reference curve. Septal abnormality scores on stress images were 0.8 +/- 22 for group I, 27 +/- 43 for group II, and 165 +/- 67 for group III (p = 0.15 for group I vs II, and p0.0001 between groups I and III, and II and III).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|