Associations of Interleukin-5 With Plaque Development and Cardiovascular Events
| Autor: | Anna Hultgårdh Nilsson, Pontus Dunér, Gunnar Engström, Christoph J. Binder, Jan Nilsson, Harry Björkbacka, Anki Knutsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty MACE major adverse cardiac events Carotid arteries interleukin 5 IL-5 interleukin-5 030204 cardiovascular system & hematology CVD cardiovascular disease 03 medical and health sciences PRECLINICAL RESEARCH 0302 clinical medicine Internal medicine medicine Myocardial infarction Prospective cohort study Interleukin 5 Stroke ApoE apolipoprotein E business.industry Plasma levels medicine.disease stroke HR hazard ratio 3. Good health Acute cardiovascular disease Oscillatory blood flow OR odds ratio 030104 developmental biology myocardial infarction ILC2 type 2 innate lymphoid cells lcsh:RC666-701 Cardiology atherosclerosis Cardiology and Cardiovascular Medicine business Editorial Comment |
| Zdroj: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 891-902 (2019) |
| ISSN: | 2452-302X |
| Popis: | Visual Abstract Highlights • There is strong experimental evidence that IL-5 has a protective role in atherosclerosis but the clinical importance of this remains poorly studied. • In a prospective study involving 696 subjects with a follow-up of close to 17 years we show that baseline plasma levels of IL-5 do not predict risk for coronary events and stroke. • However, subjects with high levels of IL-5 were less likely to have a carotid plaque at the baseline investigation. • Experimental studies using a shear stress-modifying cast to the carotid artery of Apoe−/− mice deficient for IL-5 showed that lack of IL-5 was associated with increased plaque formation at sites of oscillatory blood flow. • The findings are in line with previous experimental observations of an atheroprotective role of IL-5 but do not support the use of IL-5 measurement in cardiovascular risk prediction. Summary Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development. |
| Databáze: | OpenAIRE |
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