Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans
| Autor: | David R. Mann, Terry Gimpel, V. Daniel Castracane, A Johnson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Central nervous system Receptors Cell Surface Biology Biochemistry Endocrinology Sex Factors Predictive Value of Tests Internal medicine Blood plasma medicine Humans Testosterone Child Leptin receptor digestive oral and skin physiology Biochemistry (medical) Puberty Age Factors Infant Newborn Infant Estrogens Androgen medicine.anatomical_structure Estrogen Child Preschool Receptors Leptin Female Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 88(7) |
| ISSN: | 0021-972X |
| Popis: | We determined developmental changes in circulating levels of the soluble leptin receptor (sOB-R), leptin, and gonadal hormones in human subjects. In both sexes the rise in leptin with age was associated with a decline in sOB-R, and age-related changes in both parameters preceded the pubertal rise in gonadal hormones. Leptin levels above 10 ng/ml were a strong predictor of sOB-R concentrations, but this predictive value decreased as leptin declined. In young subjects there were no gender differences in serum leptin, but boys had higher sOB-R levels. In adults neither leptin nor sOB-R changed with age, but serum leptin was higher and sOB-R was lower in women than men. There was a significant negative correlation between sOB-R and leptin in women, but not men. The data suggest that bioavailable leptin in the circulation may be increasing more rapidly during development than indicated by total leptin levels, and that these changes may serve as one of the signals to the central nervous system that metabolic conditions are adequate to support pubertal development. Furthermore, the study provides suggestive evidence that leptin regulates the secretion of its own binding protein, but it also appears that an additional gender-specific, leptin-independent, regulatory mechanism is functional before puberty. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|