Action of pentoxifylline on experimental cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis
| Autor: | Mário Capp Neto, Helbert Abe Rodrigues, Rosa Maria Parreiras Antonino, Thiago de Sá Oliveira, Albino Verçosa de Magalhães, Bernardo José Alves Martins |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty alpha lcsh:Arctic medicine. Tropical medicine Time Factors Leishmania (Leishmania) amazonensis lcsh:RC955-962 medicine.medical_treatment Leishmania mexicana lcsh:QR1-502 Leishmaniasis Cutaneous Inflammation Biology Pharmacology lcsh:Microbiology Pentoxifylline Mice Necrosis Immune system tumour necrosis factor Cutaneous leishmaniasis medicine Leishmaniose Animals Enzyme Inhibitors Fator de necrose de tumor Macrophages Leishmaniasis Immunotherapy medicine.disease Leishmania biology.organism_classification Leishmaniose cutânea Disease Models Animal pentoxifylline Immunology Histopathology Female medicine.symptom medicine.drug |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 95, Iss 4, Pp 477-482 (2000) Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB Memórias do Instituto Oswaldo Cruz, Volume: 95, Issue: 4, Pages: 477-482, Published: AUG 2000 |
| ISSN: | 0074-0276 |
| Popis: | In the animal model of leishmaniasis caused by Leishmania (Leishmania) amazonensis there is a complex mechanism of the host-parasite interaction. The present study was performed to interfere with the inflammatory reaction to the parasites, through immune modulation. Female C5BL/6 isogenic mice were used, some of which were inoculated on the right ear and others on the right footpad with 3.10(6) stationary phase promastigotes of the MHOM/BR/PH8 strain of L. (L.) amazonensis, and were allocated in three groups: the first received pentoxifylline 8mg/kg every 12 h, since the first day; the second one received the same dose since the 40th day of infection and a control group that did not receive any treatment. All the ears excised were analyzed to determine the variation in weight between both ears and for histopathological analyses. A quantification of the parasites was done using the limiting dilution assay. A significant reduction of the number of parasites, was observed among the animals treated which had an accordingly significant reduction on the weight of the ears. Pentoxifylline reduced the macrophages propensity to vacuolation and induced a more effective destruction of the parasites by these cells. Moreover, the group that began the treatment later did not show the same effectiveness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|