Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients

Autor: Celestine F. Williams, Cees Vermeer, Norman K. Pollock, Anas Raed, William D. Paulson, Mary Ellen Fain, Gaston Kapuku, Marjo H. J. Knapen, Yanbin Dong
Přispěvatelé: Ondersteunend personeel CD, RS: CARIM - R1.02 - Vascular aspects thrombosis and haemostasis
Rok vydání: 2017
Předmět:
CHRONIC KIDNEY-DISEASE
Male
medicine.medical_treatment
030232 urology & nephrology
030204 cardiovascular system & hematology
FOS: Health sciences
SUPPLEMENTATION
vitamin K
0302 clinical medicine
endothelial function
Risk Factors
Matrix gla protein
Endothelial dysfunction
African American
Pulse wave velocity
education.field_of_study
Extracellular Matrix Proteins
biology
blood pressure
AORTIC STIFFNESS
Middle Aged
111103 Nutritional Physiology
Up-Regulation
medicine.anatomical_structure
arterial stiffness
Cardiovascular Diseases
Cardiology
Medicine
Female
Hemodialysis
Adult
medicine.medical_specialty
hypertension
Endothelium
Population
CALCIUM
03 medical and health sciences
Young Adult
Vascular Stiffness
VASCULAR CALCIFICATION
Renal Dialysis
Internal medicine
Internal Medicine
medicine
Humans
education
CARDIOVASCULAR EVENTS
Aged
business.industry
MORTALITY
Calcium-Binding Proteins
VITAMIN-K STATUS
medicine.disease
DIALYSIS PATIENTS
Black or African American
RENAL-DISEASE
Blood pressure
Cross-Sectional Studies
Case-Control Studies
Arterial stiffness
biology.protein
Kidney Failure
Chronic
Endothelium
Vascular
business
chronic kidney disease
Biomarkers
Zdroj: American Journal of Hypertension, 31(6), 735-741. Oxford University Press
ISSN: 1941-7225
0895-7061
Popis: BACKGROUND Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) risk. Despite African Americans experiencing highest rates of kidney failure and CVD events, relationships between dp-ucMGP and CVD risk markers have not been examined in this population. We investigated vascular vitamin K status (via plasma dp-ucMGP) between African American hemodialysis (HD) patients and healthy controls, and the associations of dp-ucMGP with arterial stiffness and endothelial function in HD patients only. METHODS In 37 African American HD patients and 37 age- and race-matched controls, plasma dp-ucMGP was measured by enzyme immunoassay as a marker of vascular vitamin K status. Carotid-femoral pulse wave velocity (PWV; arterial stiffness measurement) and brachial artery flow-mediated dilation (FMD; endothelial function measurement) were assessed by applanation tonometry and ultrasound, respectively, in HD patients only. RESULTS Mean dp-ucMGP levels were 5.6 times higher in HD patients vs. controls (2,139 +/- 1,102 vs. 382 +/- 181 pmol/l, P < 0.01). Multiple linear regression, adjusting for age, sex, dialysis vintage, diabetes mellitus, CVD history, body mass index, and blood pressure, revealed that dp-ucMGP was independently related to PWV (standardized beta = 0.49) and FMD (standardized beta = -0.53) (both P < 0.01). CONCLUSIONS Our data suggest that the higher plasma dp-ucMGP concentrations found in African American HD patients may be associated with greater arterial stiffness and endothelial dysfunction.
Databáze: OpenAIRE
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