The Molar Ratio of Total Branched-chain Amino Acids to Tyrosine Predicts a Digit Symbol Test Abnormality in Cirrhotic Patients
| Autor: | Akiyoshi Kinoshita, Jinya Ishida, Tomohisa Ishikawa, Masayuki Saruta, Yasuko Konakahara, Atsushi Hokari, Yusuke Mizuno, Akemi Kobayashi, Hironobu Hama |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis hepatic encephalopathy Serum albumin Nutritional Status 030204 cardiovascular system & hematology FFQ Gastroenterology 03 medical and health sciences 0302 clinical medicine Valine Internal medicine Internal Medicine medicine Humans Hepatic encephalopathy Aged Retrospective Studies Aged 80 and over Prothrombin time medicine.diagnostic_test biology business.industry Hazard ratio General Medicine Middle Aged digit symbol test medicine.disease BTR biology.protein Tyrosine Original Article Female 030211 gastroenterology & hepatology Abnormality Isoleucine business Amino Acids Branched-Chain Biomarkers |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.4298-19 |
| Popis: | Objective We aimed to investigate the association between the digit symbol test (DST) and clinical characteristics, including the nutritional status of liver cirrhosis patients. Methods Fifty-nine cirrhotic patients without a history of overt hepatic encephalopathy were retrospectively evaluated. We examined neuropsychological abnormalities (NPAs) using the DST. We also estimated the detailed nutritional status using the Food Frequency Questionnaire (FFQ). The patients were divided into two groups according to their DST status: patients with normal DST scores (DST-Nor group, n=45) and those with abnormal DST scores (DST-Abn group, n=14). The clinical and nutritional findings of the two groups were compared. Results Overall, 14 (23.7%) patients had a DST abnormality. There were significant differences between the two groups in serum albumin (Alb; p=0.0043), valine (Val; p=0.0016), leucine (Leu; p=0.0078), isoleucine (Ile; p=0.0022), the molar ratio of total branched-chain amino acids to tyrosine (BTR; p=0.00025), total-bilirubin (T-Bil; p=0.0071), prothrombin time (%) (PT; p=0.028), and serum sodium (Na; p=0.035). A multivariate analysis found the BTR to be the only independent predictor of a DST abnormality (hazard ratio, 9.24; p |
| Databáze: | OpenAIRE |
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