Bone mineral density at diagnosis determines fracture rate in children with acute lymphoblastic leukemia treated according to the DCOG-ALL9 protocol

Autor: Anjo J.P. Veerman, Wim C. J. Hop, Jan C. Roos, Jan A. Leeuw, Inge M. van der Sluis, Wouter J.W. Kollen, Jos P.M. Bökkerink, Mariël L. te Winkel, Rob Pieters, Marrie C. A. Bruin, Hester A. de Groot-Kruseman, Marry M. van den Heuvel-Eibrink
Přispěvatelé: Pediatrics, Epidemiology, Hematology, Radiology and nuclear medicine, Pediatric surgery, CCA - Innovative therapy
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
medicine.medical_specialty
Childhood acute lymphoblastic leukemia
Histology
Multivariate analysis
BODY-COMPOSITION
Bone density
Physiology
Endocrinology
Diabetes and Metabolism
Lymphoblastic Leukemia
Osteoporosis
Lumbar vertebrae
Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]
MASS
Fractures
Bone
MORBIDITY
Bone Density
Risk Factors
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Bone mineral density
Humans
Child
Childhood Acute Lymphoblastic Leukemia
Netherlands
Bone mineral
Lumbar Vertebrae
business.industry
Incidence
Incidence (epidemiology)
X-RAY ABSORPTIOMETRY
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Surgery
medicine.anatomical_structure
Multivariate Analysis
Linear Models
T-CELLS
Female
Steroids
business
Fractures
Zdroj: Bone, 59, 223-228. Elsevier Inc.
Bone, 59, 223-228. ELSEVIER SCIENCE INC
Bone, 59, 223-8
Bone, 59, pp. 223-8
BONE, 59, 223-228
te Winkel, M L, Pieters, R, Hop, W C J, Roos, J C, Bokkerink, J P M, Leeuw, J A, de Bruin, M C A, Kollen, W J W, Veerman, A J P, de Groot-Kruseman, H A, van der Sluis, I M & van den Heuvel-Eibrink, M M 2014, ' Bone mineral density at diagnosis determines fracture rate in children with acute lymphoblastic leukemia treated according to the DCOG-ALL9 protocol ', Bone, vol. 59, pp. 223-228 . https://doi.org/10.1016/j.bone.2013.11.017
ISSN: 8756-3282
DOI: 10.1016/j.bone.2013.11.017
Popis: Item does not contain fulltext PURPOSE: To elucidate incidence and risk factors of bone mineral density and fracture risk in children with Acute Lymphoblastic Leukemia (ALL). METHODS: Prospectively, cumulative fracture incidence, calculated from diagnosis until one year after cessation of treatment, was assessed in 672 patients. This fracture incidence was compared between subgroups of treatment stratification and age subgroups (Log-Rank test). Serial measurements of bone mineral density of the lumbar spine (BMDLS) were performed in 399 ALL patients using dual energy X-ray absorptiometry. We evaluated risk factors for a low BMD (multivariate regression analysis). Osteoporosis was defined as a BMDLS
Databáze: OpenAIRE
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