Surface Immunoglobulins on Lymphocytes in Chronic Lymphocytic Leukaemia and Lymphosarcoma
| Autor: | J. D. Wilson, A. D. F. Hurdle |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Pathology medicine.medical_specialty Surface Immunoglobulin T-Lymphocytes T cell Population Immunoglobulins Leukocyte Count Iodine Isotopes hemic and lymphatic diseases medicine Humans Lymphocytes education B cell Aged B-Lymphocytes education.field_of_study Lymphocytic leukaemia business.industry Lymphoma Non-Hodgkin Cell Membrane Hematology Middle Aged Peripheral blood Immunoglobulin A Leukemia Lymphoid medicine.anatomical_structure Immunoglobulin M Immunoglobulin G Immunology Autoradiography Female business Abnormal Lymphocyte |
| Zdroj: | British Journal of Haematology. 24:563-569 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1973.tb01682.x |
| Popis: | Summary. The density of surface immunoglobulins on peripheral blood lymphocytes from 10 patients with chronic lymphocytic leukaemia (CLL) and three patients with lymphosarcoma was examined using a sandwich radio-immunolabelling technique. In healthy people two populations of lymphocytes are seen: densely labelled cells with a high surface immunoglobulin density or B cells and lightly labelled T cells. CLL lymphocytes were found to comprise a single population with labelling characteristics of B lymphocytes in eight patients and of T lymphocytes in two patients. In the three lymphosarcoma patients grain count histograms revealed two or three populations where the abnormal lymphocytes fell into the T cell type in two and into the B cell group in one patient. There were no essential clinical differences between these three patients. |
| Databáze: | OpenAIRE |
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