How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair
| Autor: | Petra Mitrengová, Pavol Szabo, Pavel Mučaji, Petr Gál, Andrej Mirossay, Lenka Varinská, Karel Smetana, Stepan Novak, Lenka Fáber |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell signaling Chemokine Galectins Pharmaceutical Science Review Analytical Chemistry Extracellular matrix lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry Neoplasms Drug Discovery medicine Tumor Microenvironment cytokine Animals Humans cancer tissue repair Physical and Theoretical Chemistry Galectin Tumor microenvironment Wound Healing galectin biology Organic Chemistry Granulation tissue Fibronectin stem cell 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment Chemistry (miscellaneous) 030220 oncology & carcinogenesis Immune System Keloid Immunology biology.protein Cancer research Neoplastic Stem Cells Molecular Medicine Cytokines Intercellular Signaling Peptides and Proteins Wounds and Injuries Wound healing Signal Transduction |
| Zdroj: | Molecules, Vol 22, Iss 11, p 1818 (2017) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry |
| ISSN: | 1420-3049 |
| Popis: | It is now suggested that the inhibition of biological programs that are associated with the tumor microenvironment may be critical to the diagnostics, prevention and treatment of cancer. On the other hand, a suitable wound microenvironment would accelerate tissue repair and prevent extensive scar formation. In the present review paper, we define key signaling molecules (growth factors, cytokines, chemokines, and galectins) involved in the formation of the tumor microenvironment that decrease overall survival and increase drug resistance in cancer suffering patients. Additional attention will also be given to show whether targeted modulation of these regulators promote tissue regeneration and wound management. Whole-genome transcriptome profiling, in vitro and animal experiments revealed that interleukin 6, interleukin 8, chemokine (C-X-C motif) ligand 1, galectin-1, and selected proteins of the extracellular matrix (e.g., fibronectin) do have similar regulation during wound healing and tumor growth. Published data demonstrate remarkable similarities between the tumor and wound microenvironments. Therefore, tailor made manipulation of cancer stroma can have important therapeutic consequences. Moreover, better understanding of cancer cell-stroma interaction can help to improve wound healing by supporting granulation tissue formation and process of reepithelization of extensive and chronic wounds as well as prevention of hypertrophic scars and formation of keloids. |
| Databáze: | OpenAIRE |
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