| Autor: |
S. Keith Nixon, Mariano G.S. Vieira, David Attwood, Stephen G. Yeates, Marcos Carlos de Mattos, Maria Elenir Nobre Pinho Ribeiro, Nágila M.P.S. Ricardo, Carolina L. de Moura, Nilce V. Gramosa, Chiraphon Chaibundit |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 436:631-635 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/j.ijpharm.2012.07.032 |
| Popis: |
The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities of other poly(ethylene oxide)-based copolymers. UV/Vis and (1)H NMR spectroscopies were used to quantify the enhancement of solubility of griseofulvin in 1 wt% aqueous micellar solutions of Brij 78 (C(18)H(37)E(20)), Brij 98 (C(18)H(35)E(20)) and Brij 700 (C(18)H(37)E(100)) (where E represents the OCH(2)CH(2) unit of the poly(ethylene oxide) chain) at 25, 37 and 40 °C. Solubilisation capacities (S(cp) expressed as mg griseofulvin per g Brij) were similar for Brij 78 and 98 (range 6-11 mg g(-1)) but lower for Brij 700 (3-4 mg g(-1)) as would be expected for the surfactant with the higher ethylene oxide content. The drug loading capacity of micelles of Brij 78 was higher than many di- and triblock copolymers with hydrophilic E-blocks specifically designed for enhancement of drug solubility. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect