Levels of HIV-1 in subgingival biofilm of HIV-infected patients
| Autor: | Priscila Pavan, Milton de Uzeda, Viviane Tiago Pereira, Luciana Jesus da Costa, Celso Oliveira Souza, Carmelo Sansone, Sandra Torres, Lucio Souza Gonçalves, Ana Paula Vieira Colombo, Rodrigo Carvalho de Souza |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Dental Plaque Gingiva Human immunodeficiency virus (HIV) HIV Infections CD8-Positive T-Lymphocytes Biology medicine.disease_cause Gastroenterology Young Adult Antiretroviral Therapy Highly Active Internal medicine Periodontal Attachment Loss medicine Humans Periodontal Pocket Hiv infected patients Lymphocyte Count Viremia Significant difference Viral Load Individual level medicine.disease Chronic periodontitis CD4 Lymphocyte Count Biofilms Chronic Periodontitis HIV-1 Periodontics Female Gingival Hemorrhage Viral load Subgingival biofilm |
| Zdroj: | Journal of Clinical Periodontology. 41:1061-1068 |
| ISSN: | 0303-6979 |
| DOI: | 10.1111/jcpe.12306 |
| Popis: | Aim The aims of the current study were to compare the levels of HIV-1 in the subgingival biofilm (SHVL) between detectable and undetectable plasmatic HIV-1 viral load (PHVL) in HIV-infected patients as well as to determine the association of SHVL with PHVL and clinical periodontal parameters. Material and Methods Forty-one HIV-infected individuals were divided into two groups: detectable (21) and undetectable (20) PHVL. Subgingival biofilm samples were obtained for detection and quantification of HIV-1 by real-time RT-PCR. To estimate the effect of co-variables on the outcome undetectable SHVL, the Generalized Estimation Equation (GEE) was employed. Results Detectable SHVL was observed only in the detectable PHVL group and the detection of the HIV-1 was observed in 40% of these individuals. In the bivariate analysis between co-variables from the individual level and the outcome SHVL, significant difference was observed only for the CD4+ T lymphocytes levels (p = 0.017). The multiple logistic model demonstrated that only CD4+ T lymphocytes levels had a significant effect on the outcome undetectable SHVL [OR 8.85 (CI 3.6–9.2), p = 0.002]. Conclusion HIV-1 can be detected and quantified in the subgingival biofilm of HIV-infected individuals, but these findings are not associated with PHVL and periodontal clinical parameters. |
| Databáze: | OpenAIRE |
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