Using Chitosan or Chitosan Derivatives in Cancer Therapy
| Autor: | Md. Sakib Hossen, Md. Forhad Uddin, Mohammad Sayem, Salman Shakil, Kazi Mustafa Mahmud, Mahruba Sultana Niloy, Md. Ashraful Hasan, Sajal Kumar Halder |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biocompatibility
medicine.medical_treatment chitosan derivatives Cancer therapy technology industry and agriculture Immunotherapy Drug resistance macromolecular substances QD415-436 Pharmacology equipment and supplies Biochemistry Chitosan carbohydrates (lipids) chemistry.chemical_compound anticancer activities Chitin chemistry Drug delivery medicine immunotherapy chitosan Cytotoxicity gene and drug delivery |
| Zdroj: | Polysaccharides, Vol 2, Iss 48, Pp 795-816 (2021) |
| ISSN: | 2673-4176 |
| Popis: | Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy. |
| Databáze: | OpenAIRE |
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