Sleep-wake rhythm disruption is associated with cancer-related fatigue in pediatric acute lymphoblastic leukemia
| Autor: | Martha A. Grootenhuis, Gertjan J.L. Kaspers, Natasha K. A. van Eijkelenburg, Wim J. E. Tissing, Cor van den Bos, Inge M. van der Sluis, Eus J.W. Van Someren, Raphaële R. L. van Litsenburg, Natasja Dors, Lindsay M.H. Steur |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Pediatric surgery, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, CCA - Cancer Treatment and quality of life, APH - Methodology, Integrative Neurophysiology, Pediatrics, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Rok vydání: | 2020 |
| Předmět: |
Sleep
Health and Disease Cancer Fatigue children sleep-wake rhythms physical activity CHILDREN THERAPY 0302 clinical medicine Quality of life QUALITY-OF-LIFE MELATONIN SECRETION ADOLESCENTS Medicine Child Cancer-related fatigue Fatigue Sleep hygiene AcademicSubjects/SCI01870 Precursor Cell Lymphoblastic Leukemia-Lymphoma Circadian Rhythm DEXAMETHASONE LIGHT 030220 oncology & carcinogenesis medicine.symptom medicine.drug AcademicSubjects/MED00370 medicine.medical_specialty Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] acute lymphoblastic leukemia Melatonin 03 medical and health sciences SDG 3 - Good Health and Well-being Physiology (medical) Internal medicine Acute lymphocytic leukemia Humans Circadian rhythm AcademicSubjects/MED00385 HOME business.industry CIRCADIAN-RHYTHM Actigraphy cancer-related fatigue medicine.disease Neurology (clinical) business Sleep 030217 neurology & neurosurgery actigraphy children sleep–wake rhythms |
| Zdroj: | Sleep, 43, 6 Sleep, 43:zsz320. American Academy of Sleep Medicine Sleep, 43(6). American Academy of Sleep Medicine Sleep Sleep, 43(6):zsz320. Oxford University Press Sleep, 43 Steur, L M H, Kaspers, G J L, Van Someren, E J W, Van Eijkelenburg, N K A, Van der Sluis, I M, Dors, N, Van den Bos, C, Tissing, W J E, Grootenhuis, M A & Van Litsenburg, R R L 2020, ' Sleep-wake rhythm disruption is associated with cancer-related fatigue in pediatric acute lymphoblastic leukemia ', Sleep, vol. 43, no. 6 . https://doi.org/10.1093/sleep/zsz320 Sleep, 43(6):320. Oxford University Press |
| ISSN: | 0161-8105 |
| Popis: | Study Objectives To compare sleep–wake rhythms, melatonin, and cancer-related fatigue in pediatric patients with acute lymphoblastic leukemia (ALL) to healthy children and to assess the association between sleep–wake outcomes and cancer-related fatigue. Methods A national cohort of ALL patients (2–18 years) was included. Sleep–wake rhythms were measured using actigraphy and generated the following variables: Interdaily stability (IS): higher IS reflects higher stability; intradaily variability (IV): lower IV indicates less fragmentation; L5 and M10 counts: activity counts during the five least and 10 most active hours, respectively; and relative amplitude (RA): the ratio of L5 and M10 counts (higher RA reflects a more robust rhythm). The melatonin metabolite, 6-sulfatoxymelatonin (aMT6s), was assessed in urine. Cancer-related fatigue was assessed with the PedsQL Multidimensional Fatigue Scale. Using regression models sleep–wake rhythms, aMT6s, and cancer-related fatigue were compared to healthy children and associations between sleep–wake outcomes and cancer-related fatigue were assessed in ALL patients. Results In total, 126 patients participated (response rate: 67%). IS, RA, and M10 counts were lower in patients compared to healthy children (p < 0.001). aMT6s levels were comparable to healthy children (p = 0.425). Patients with ALL were more fatigued compared to healthy children (p < 0.001). Lower IS, RA and M10 counts and higher IV were significantly associated with more parent-reported cancer-related fatigue. Associations between sleep–wake rhythms and self-reported cancer-related fatigue were not statistically significant. Conclusions Sleep–wake rhythm impairment is associated with more cancer-related fatigue in pediatric ALL patients. Interventions aimed to improve sleep hygiene and encourage physical activity may reduce cancer-related fatigue. |
| Databáze: | OpenAIRE |
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