| Autor: |
Ryan K Shields, Madison E Stellfox, Ellen G Kline, Palash Samanta, Daria Van Tyne |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Clin Infect Dis |
| Popis: |
We report the emergence of imipenem-relebactam nonsusceptible Pseudomonas aeruginosa in 5 patients treated for nosocomial pneumonia for 10–28 days. Genome sequence analysis identified treatment-emergent mutations in MexAB-OprM and/or MexEF-OprN efflux operons that arose independently in each patient across distinct P. aeruginosa sequence types. Testing with efflux-inhibitor PAβN restored imipenem-relebactam susceptibility. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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