Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study
| Autor: | Íñigo María Pérez-Castillo, María José Aguilar-Cordero, María Setefilla López-Criado, Ximena Alejandra Leon-Rios, Manuela Expósito-Ruiz, Tania Rivero-Blanco |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Parathyroid hormone
Physiology chemistry.chemical_compound 0302 clinical medicine Pregnancy perinatal adverse outcomes Prospective Studies 030212 general & internal medicine phosphorus Vitamin D Prospective cohort study Nutrition and Dietetics Pregnancy Outcome Phosphorus 25-hydroxyvitamin D Perinatal adverse outcomes Premature Birth Female medicine.symptom Cohort study lcsh:Nutrition. Foods and food supply PTH Adult Vitamin vitamin D deficiency Nutritional Status lcsh:TX341-641 030209 endocrinology & metabolism Article Young Adult 03 medical and health sciences cohort study medicine Vitamin D and neurology parathyroid hormone Humans calcium business.industry Infant Newborn Maternal Nutritional Physiological Phenomena Infant Low Birth Weight medicine.disease Pregnancy Complications Low birth weight Logistic Models chemistry Small for gestational age Calcium business Food Science |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Nutrients Nutrients, Vol 12, Iss 3279, p 3279 (2020) Volume 12 Issue 11 Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) |
| DOI: | 10.3390/nu12113279 |
| Popis: | Vitamin D deficiency during pregnancy has been linked to perinatal adverse outcomes. Studies conducted to date have recommended assessing interactions with other vitamin D-related metabolites to clarify this subject. We aimed to evaluate the association of vitamin D deficiency during early pregnancy with preterm birth. Secondary outcomes included low birth weight and small for gestational age. Additionally, we explored the role that parathyroid hormone, calcium and phosphorus could play in the associations. We conducted a prospective cohort study comprising 289 pregnant women in a hospital in Granada, Spain. Participants were followed-up from weeks 10&ndash 12 of gestation to postpartum. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus were measured within the first week after recruitment. Pearson&rsquo s &chi 2 test, Mann&ndash Whitney U test, binary and multivariable logistic regression models were used to explore associations between variables and outcomes. 36.3% of the participants were vitamin D deficient (< 20 ng/mL). 25-hydroxyvitamin D concentration was inversely correlated with parathyroid hormone (&rho = &minus 0.146, p = 0.013). Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Calcium and phosphorus were not associated with any studied outcome. Combined measurement of 25-hydroxyvitamin D and parathyroid hormone could be a better estimator of preterm birth than vitamin D in isolation. |
| Databáze: | OpenAIRE |
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