Pregnancy in Sickle Cell Disease Is a Very High-Risk Situation: An Observational Study

Autor: John Balcaen, Laetitia Accrombessi, Gabriel Carles, Aurélie Adeline, Narcisse Elenga, Anne Terraz, Tania Vaz, Mélanie Calvez
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Obstetrics and Gynecology International
Obstetrics and Gynecology International, Vol 2016 (2016)
ISSN: 1687-9597
1687-9589
Popis: Sickle cell disease is a serious genetic disorder affecting 1/235 births in French Guiana. This study aimed to describe the follow-up of pregnancies among sickle cell disease patients in Cayenne Hospital, in order to highlight the most reported complications. 62 records of pregnancies were analyzed among 44 females with sickle cell disease, between 2007 and 2013. Our results were compared to those of studies conducted in Brazil and Guadeloupe. There were 61 monofetal pregnancies and 2 twin pregnancies, 27 pregnancies among women with SS phenotype, 30 SC pregnancies, and five S-beta pregnancies. The study showed that the follow-up of patients was variable, but no maternal death was found. We also noted that the main maternofetal complications of pregnancies were anemia (36.5%), infection (31.7%), vasoocclusive crisis (20.6%), preeclampsia (17.5%), premature birth (11.1%), intrauterine growth retardation (15.9%), abnormal fetal heart rate (14.3%), and intrauterine fetal death (4.8%). Pregnancies were more at risk among women with SS phenotype. Pregnancy in sickle cell disease patients requires a supported multidisciplinary team including the primary care physician, the obstetrician, and the Integrated Center for Sickle Cell Disease.
Databáze: OpenAIRE
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