Possible association between suicide committed under influence of ethanol and a variant in the AUTS2 gene
| Autor: | Aleksandra Pawlak, Izabela Chojnicka, Pawe lstrok Krajewski, Grażyna Broda, Krzysztof Gajos, Marcin Fudalej, Rafał Płoski, Piotr Stawiński, Sylwia Fudalej, Marcin Wojnar, Katarzyna Strawa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Gene Identification and Analysis lcsh:Medicine Poison control Social and Behavioral Sciences Suicide prevention 0302 clinical medicine Gene Frequency Sociology Genotype lcsh:Science Genes Dominant Genetics Psychiatry 0303 health sciences education.field_of_study Multidisciplinary Substance Abuse Middle Aged Suicide Mental Health Cohort Medicine Female Research Article Adult medicine.medical_specialty Alcohol Drinking Population Neuropsychiatric Disorders Polymorphism Single Nucleotide White People Molecular Genetics 03 medical and health sciences Internal medicine medicine Humans Allele education Allele frequency Genotyping Biology Alleles Genetic Association Studies 030304 developmental biology Ethanol business.industry lcsh:R Proteins Human Genetics Cytoskeletal Proteins Endocrinology Genetics of Disease Genetic Polymorphism lcsh:Q business 030217 neurology & neurosurgery Population Genetics Transcription Factors |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 2, p e57199 (2013) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: rs6943555 in AUTS2 has been shown to modulate ethanol consumption. We hypothesized that rs6943555 might be associated with completed suicide. METHODS: We genotyped rs6943555 in 625 completed suicides and 3861 controls using real-time TaqMan Allelic Discrimination Assay. All individuals were Polish Caucasians. RESULTS: We detected an association between suicide and rs6943555 A allele (OR = 1.17, P = 0.018 for allelic comparison, OR = 1.24, P = 0.013 for dominant, and OR = 1.18, P = 0.020 for co-dominant model of inheritance). The association remained significant after adjusting for age and gender (co-dominant: P = 0.002 and dominant model: P = 0.001). After stratifying suicides according to blood ethanol concentration (BAC≤ 20 mg/dl and BAC > 20 mg/dl) the association remained significant only for cases who committed suicide under influence of alcohol (co-dominant: OR = 1.37, P = 0.004 and dominant model: OR = 1.45, P = 0.006). To validate this finding we genotyped another cohort of 132 cases. We reproduced the association between rs6943555 A allele and suicide under influence of ethanol (allelic comparison: OR = 1.55, P = 0.023; co-dominant : OR = 1.54, P = 0.031; dominant model: OR = 1.84, P = 0.015). Analyzing pooled suicides with BAC >20 mg/dl (N = 300) we found the association of rs6943555 A allele not only vs. controls (allelic OR = 1.41, P = 0.00029) but also vs. cases with BAC ≤ 20 mg/dl (N = 449, allelic OR = 1.33, P = 0.019). CONCLUSIONS: In our study rs6943555 A allele is associated with suicide committed after drinking ethanol shortly before death. The rs6943555 A allele may be linked to adverse emotional reaction to ethanol, which could explain the association with lower consumption in general population as well as the predisposition to suicide under influence of ethanol. Language: en |
| Databáze: | OpenAIRE |
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