Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy
| Autor: | Mohammed A. W. ElKhatib, Fadumo Ahmed Isse, Ayman O. S. El-Kadi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Drug metabolism reviews. |
| ISSN: | 1097-9883 |
| Popis: | The incidence of heart failure (HF) is generally preceded by cardiac hypertrophy (CH), which is the enlargement of cardiac myocytes in response to stress. During CH, the metabolism of arachidonic acid (AA), which is present in the cell membrane phospholipids, is modulated. Metabolism of AA gives rise to hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs) |
| Databáze: | OpenAIRE |
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