Mortality among sheet metal workers participating in a medical screening program
| Autor: | Douglas J. Myers, Elizabeth Haile, Laura S. Welch, John M. Dement |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Lung Diseases Male Canada medicine.medical_specialty Lung Neoplasms Adolescent Asbestosis Poison control Cohort Studies Young Adult Disease Screening Risk Factors Occupational Exposure Environmental health Confidence Intervals Humans Mass Screening Medicine Child Lung cancer Occupational Health Mass screening Aged Proportional Hazards Models Aged 80 and over Models Statistical Construction Materials business.industry Proportional hazards model Mortality rate Public Health Environmental and Occupational Health Infant Middle Aged respiratory system medicine.disease United States respiratory tract diseases Surgery Occupational Diseases Metals Child Preschool Multivariate Analysis Female business Cohort study |
| Zdroj: | American Journal of Industrial Medicine. 52:603-613 |
| ISSN: | 1097-0274 0271-3586 |
| DOI: | 10.1002/ajim.20725 |
| Popis: | Background The Sheet Metal Occupational Health Institute Trust (SMOHIT) was formed in 1985 to examine the health hazards of the sheet metal industry in the U.S. and Canada through an asbestos disease screening program. A study of mortality patterns among screening program participants was undertaken. Methods A cohort of 17,345 individuals with 20 or more years in the trade and who participated in the asbestos disease screening program were followed for vital status and causes of death between 1986 and 2004. Data from the screening program included chest X-ray results by International Labour Office (ILO) criteria and smoking history. Standardized mortality ratios (SMRs) by cause were generated using U.S. death rates and Cox proportional hazards models were used to investigate lung cancer risk relative to chest X-ray changes while controlling for smoking. Results A significantly reduced SMR of 0.83 (95% CI = 0.80–0.85) was observed for all causes combined. Statistically significant excess mortality was observed for pleural cancers, mesothelioma, and asbestosis in the SMR analyses. Both lung cancer and COPD SMRs increased consistently and strongly with increasing ILO profusion score. In Cox models, which controlled for smoking, increased lung cancer risk was observed among workers with ILO scores of 0/1 (RR = 1.17, 95% CI = 0.89–1.54), with a strong trend for increasing lung cancer risk with increasing ILO profusion score >0/0. Conclusions Sheet metal workers are at increased risk for asbestos-related diseases. This study contributes to the literature demonstrating asbestos-related diseases among workers with largely indirect exposures and supports an increased lung cancer risk among workers with low ILO profusion scores. Am. J. Ind. Med. 52:603–613, 2009. © 2009 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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