The Increment of Short-term Variability of Repolarisation Determines the Severity of the Imminent Arrhythmic Outcome
| Autor: | Agnieszka Smoczyńska, Marc A. Vos, H D M Beekman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cardiomyopathy Torsades de pointes Physiology (medical) Internal medicine medicine Diseases of the circulatory (Cardiovascular) system Myocardial infarction cardiovascular diseases Stroke business.industry Short Term Variability beat-to-beat variation of repolarisation ventricular arrhythmias Atrial fibrillation medicine.disease RC666-701 Heart failure Cardiology cardiovascular system Clinical Arrhythmias torsades de pointes Cardiology and Cardiovascular Medicine business Atrioventricular block Short-term variability of repolarisation |
| Zdroj: | Arrhythmia & Electrophysiology Review Arrhythmia & Electrophysiology Review, Vol 8, Iss 3, Pp 166-172 (2019) |
| ISSN: | 2050-3377 2050-3369 |
| Popis: | Ventricular remodelling can make the heart more susceptible to ventricular arrhythmias like torsades de pointes. Understanding the underlying mechanisms of initiation of ventricular arrhythmias and the determining factors for its severity has the potential to uncover new interventions. Beat-to-beat variation of repolarisation, quantified as short-term variability of repolarisation (STV), has been identified as an important factor contributing to arrhythmogenesis. This article provides an overview of experimental data about STV in relation to the initiation of torsades de pointes in a canine model of complete chronic atrioventricular block susceptible to torsades de pointes arrhythmias. Furthermore, it explores STV in relation to the severity of the arrhythmic outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|