Radiation therapy for breast cancer and clonal chromosome translocations: A fluorescence in situ hybridization study
| Autor: | Inkeri Elomaa, Päivi Majander, Mikko Tenhunen, Sakari Knuutila, Tiina Saarto, Marcelo L. Larramendy, Rosa Caballín |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
In situ
Cancer Research medicine.medical_specialty Molecular biology Biología medicine.medical_treatment Breast Neoplasms Chromosomal translocation Breast Neoplasms/genetics Breast Adenocarcinoma Biology Translocation Genetic Cytogenetics 03 medical and health sciences Breast cancer 0302 clinical medicine Genetics medicine Humans Molecular Biology Metaphase In Situ Hybridization Fluorescence Aged 030304 developmental biology 0303 health sciences medicine.diagnostic_test Fluorescence in situ hybridization Middle Aged medicine.disease 3. Good health Radiation therapy 030220 oncology & carcinogenesis Ciencias Médicas Female |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP ResearcherID |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(97)00014-9 |
| Popis: | The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples. Facultad de Ciencias Naturales y Museo |
| Databáze: | OpenAIRE |
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