Teratogenic effects of combined use of anti-kidney serum and E-64 in the rat
| Autor: | Shen Fang Chen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Cysteine Proteinase Inhibitors Microphthalmia Leucine Pregnancy Internal medicine Medicine Animals Yolk sac Hydronephrosis Kidney Anophthalmia business.industry Immune Sera Drug Synergism Rats Inbred Strains medicine.disease Teratology Rats medicine.anatomical_structure Endocrinology Teratogens Pediatrics Perinatology and Child Health Gestation Female business |
| Zdroj: | Acta paediatrica Japonica : Overseas edition. 31(6) |
| ISSN: | 0374-5600 |
| Popis: | The teratogenic effects of rabbit anti-rat-kidney serum (AKS) combined with E-64 (a thiol protease inhibitor) were examined. Wistar rats were injected with 10 or 20 mg/kg of E-64 on days 9 and 10 of gestation, and with a subteratogenic dose (1 ml/kg) of AKS on day 9 or day 10. The most common malformations were hydronephrosis, hydrocephalus, ureteral dilatation, microphthalmia, anophthalmia, and heart defects. When AKS was given on day 9 or 10, the incidence of malformations was about 7% (10 mg/kg group) and 24% (20 mg/kg group). This indicated that the types of malformations are similar to those produced by AKS and E-64, and there is a synergistic effect between AKS and E-64. |
| Databáze: | OpenAIRE |
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