Pseudorabies virus latency: restricted transcription
| Autor: | D. G. Thawley, Thomas W Molitor, J. R. Lokensgard |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gene Expression Regulation
Viral Genes Viral Transcription Genetic Swine viruses Molecular Sequence Data Restriction Mapping Pseudorabies In situ hybridization Virus Transcription (biology) Virology Alphaherpesvirinae Virus latency medicine Animals Gene Neurons Swine Diseases biology Hybridization probe Nucleic Acid Hybridization General Medicine medicine.disease biology.organism_classification Herpesvirus 1 Suid Molecular biology DNA Viral RNA Viral |
| Zdroj: | Archives of Virology. 110:129-136 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/bf01310709 |
| Popis: | Cloned pseudorabies virus (PRV) sequences representing over 80% of the viral genome were radiolabeled and individually hybridized to nucleic acid in the trigeminal ganglia of acutely and latently infected swine. In acutely infected animals, all cloned probes hybridized to PRV RNA and DNA. In contrast, during latency transcription was found to be limited to a selected region, corresponding to the IE gene, analogous to that of two other alpha-herpesviruses. Viral DNA was not detected in latently infected neurons by in situ hybridization. |
| Databáze: | OpenAIRE |
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