Reflectance confocal microscopy-guided carbon dioxide laser ablation of low-risk basal cell carcinomas: A prospective study
| Autor: | Anthony M. Rossi, Nina R. Blank, Oriol Yélamos, Brian P. Hibler, Saud Aleissa, Miguel Cordova, Cristian Navarrete-Dechent, Aditi Sahu, Milind Rajadhyaksha, Heidy Sierra, Konstantinos Liopyris |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Reflectance confocal microscopy Neoplasm Residual Skin Neoplasms Biopsy medicine.medical_treatment Dermatology Risk Assessment Article law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine law medicine Humans Basal cell Basal cell carcinoma Prospective Studies Prospective cohort study Aged Skin Microscopy Confocal Laser ablation business.industry Middle Aged Carbon dioxide laser Laser medicine.disease Ablation Treatment Outcome Carcinoma Basal Cell 030220 oncology & carcinogenesis Lasers Gas Feasibility Studies Female Laser Therapy Neoplasm Recurrence Local business Nuclear medicine Follow-Up Studies |
| Zdroj: | J Am Acad Dermatol |
| ISSN: | 0190-9622 |
| Popis: | Background Basal cell carcinoma (BCC) treatment modalities can be stratified based on tumor subtype and recurrence risk. The main limitation of non-surgical treatment modalities is the lack of histopathological confirmation. Reflectance confocal microscopy (RCM) is a non-invasive imaging device that provides quasi-histological images. Objective To evaluate the feasibility and efficacy of RCM-guided carbon dioxide (CO2) laser ablation of low-risk BCCs. Methods Prospective study with biopsy-proven low-risk BCCs imaged with RCM. RCM was performed on these sites and ablated; if residual tumor was found, a new series of laser passes were performed. The patients were then followed for recurrence clinically and with RCM. Results Twenty-two tumor sites in nine patients were imaged and treated. Median age was 59±12.9 years (range 30 – 74). Male-to-female ratio was 5:4. Mean tumor size was 7.7 mm (range 5 – 10 mm). Residual tumor was identified in 5/22 cases (22.7%) under RCM on immediate first pass post-ablation sites, prompting additional laser passes. Median follow-up was 28.5 month (22 – 32 months) with no recurrences found. Conclusions Addition of RCM to laser ablation workflow can detect subclinical persistent tumor after initial ablation and may serve as an aid to increase the efficacy of laser ablation. |
| Databáze: | OpenAIRE |
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