Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Autor:	Sheila C. Dollard, Jordan Cates, Mónica Benavides, Minal M. Amin, Elizabeth C. Ailes, Katherine Laiton-Donato, Van T. Tong, Martha L. Ospina, Diana Valencia, Laura D. Zambrano, Jessica N Ricaldi, Tatiana M. Lanzieri, Sheryll Corchuelo, Marcela Mercado, Jacqueline Acosta, Marcela Daza, Margaret A. Honein, Angelica Rico, Phili Wong, Maritza Gonzalez, Dioselina Pelaez, Suzanne Newton, Helena Rodríguez, Suzanne M. Gilboa
Rok vydání:	2021
Předmět:	Adult medicine.medical_specialty Congenital cytomegalovirus infection Cytomegalovirus Mothers Gestational Age Urine Colombia Antibodies Viral Article 03 medical and health sciences 0302 clinical medicine Pregnancy Seroepidemiologic Studies Interquartile range Virology Epidemiology Humans Seroprevalence Medicine 030212 general & internal medicine Pregnancy Complications Infectious Saliva biology business.industry Obstetrics Infant virus diseases medicine.disease Confidence interval Infectious Diseases Child Preschool Immunoglobulin G Cytomegalovirus Infections DNA Viral biology.protein Gestation Female 030211 gastroenterology & hepatology Antibody business
Zdroj:	J Med Virol
ISSN:	1096-9071 0146-6615
DOI:	10.1002/jmv.26815
Popis:	We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8–12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%–98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%–18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%–59.1%) had postnatal infection.
Databáze:	OpenAIRE
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