Macrophages in microgravity: the impact of space on immune cells
| Autor: | Justin Silberman, Christopher Ludtka, Josephine B. Allen, Erika M. Moore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physics and Astronomy (miscellaneous) Physiology Materials Science (miscellaneous) Medicine (miscellaneous) Context (language use) Review Article Biology Biochemistry Genetics and Molecular Biology (miscellaneous) 03 medical and health sciences 0302 clinical medicine Study methods Immune system medicine Macrophage QP1-981 Acute inflammation Monocyte Chronic inflammation Agricultural and Biological Sciences (miscellaneous) 030104 developmental biology Tissue remodeling medicine.anatomical_structure Space and Planetary Science 030220 oncology & carcinogenesis Cytokine secretion Neuroscience TP248.13-248.65 Biotechnology |
| Zdroj: | npj Microgravity, Vol 7, Iss 1, Pp 1-10 (2021) NPJ Microgravity |
| ISSN: | 2373-8065 |
| Popis: | The effects of a microgravity environment on the myriad types of immune cells present within the human body have been assessed both by bench-scale simulation and suborbital methods, as well as in true spaceflight. Macrophages have garnered increased research interest in this context in recent years. Their functionality in both immune response and tissue remodeling makes them a unique cell to investigate in regards to gravisensitive effects as well as parameters of interest that could impact astronaut health. Here, we review and summarize the literature investigating the effects of microgravity on macrophages and monocytes regarding the microgravity environment simulation/generation methods, cell sources, experiment durations, and parameters of interest utilized within the field. We discuss reported findings on the impacts of microgravity on macrophage/monocyte structure, adhesion and migration, proliferation, genetic expression, cytokine secretion, and reactive oxygen species production, as well as polarization. Based on this body of data, we make recommendations to the field for careful consideration of experimental design to complement existing reports, as the multitude of disparate study methods previously published can make drawing direct comparisons difficult. However, the breadth of different testing methodologies can also lend itself to attempting to identify the most robust and consistent responses to microgravity across various testing conditions. |
| Databáze: | OpenAIRE |
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