Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship
| Autor: | Mattias Höglund, Gottfrid Sjödahl, Fredrik Liedberg, David Lindgren, Carina Bernardo, Håkan Axelson, Nour Al Dain Marzouka, Pontus Eriksson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Urologic Neoplasms
DNA Copy Number Variations lcsh:Medicine Gene mutation Biology Article Recurrent Tumor Cancer genomics Humans Tumor growth Multiple tumors Urothelium lcsh:Science Cyclin-Dependent Kinase Inhibitor p16 Chromosome Aberrations Multidisciplinary Cell growth Bladder cancer lcsh:R Oncogenes Single patient Gene Expression Regulation Neoplastic Mutation Cancer research lcsh:Q Neoplasm Recurrence Local |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-75854-4 |
| Popis: | We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient may show such changes, thus the tumors cannot have originated from each other. As recurring tumors share both genomic alterations and driver gene mutations, these must have been present in the urothelium in periods with no tumor growth. We present a model that includes a growing and evolving field of urothelial cells that occasionally, and locally, produce bursts of cellular growth leading to overt tumors. |
| Databáze: | OpenAIRE |
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