Cimetidine cholestatic jaundice in children

Autor: John R. Lilly, Norman B. Javitt, David C. Hitch
Rok vydání: 1978
Předmět:
Zdroj: Journal of Surgical Research. 24:384-387
ISSN: 0022-4804
DOI: 10.1016/0022-4804(78)90031-8
Popis: Patients. The children were 14, 3, 2, 1.5, and 1 year old (Table 1). The peptic disease was duodenal ulcer in three patients and prepyloric ulcer in two. Two patients had major duodenal ulcer hemorrhage at the time cimetidine therapy was instituted. The third patient with a duodenal ulcer had a 90% small bowel resection 3 months prior to the diagnosis of his ulcer. One of the children with a prepyloric ulcer had an associated hiatal hernia; the other had gastric outlet obstruction. Patients No. 1 and 3 had preexisting liver disease. The latter had biliary atresia treated by Kasai’s operation [3]; the etiology of the liver disease in patient No. 1 was never precisely diagnosed but could have been a consequence of long-term parenteral alimentation or chronic sepsis. Diagnosis of peptic disease was made by barium study and in two instances confirmed by endoscopy.
Databáze: OpenAIRE