High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis

Autor: Joost J. Oudejans, Sietske A. Riemersma, Maarten H. Vermeer, Patty M. Jansen, Frans A. Prins, Ed Schuuring, Paul Blok, Jettie J. F. Muris, E.J. Dreef, Philip M. Kluin, Robbie E. Kibbelaar, Marcel J. Vonk
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), Targeted Gynaecologic Oncology (TARGON), VU University medical center
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Male
Skin Neoplasms
CD3 Complex
PROTEIN EXPRESSION
HLA Antigens
T-Lymphocyte Subsets
hemic and lymphatic diseases
cytotoxic T lymphocytes (CTL)
ANTIGEN EXPRESSION
Cytotoxic T cell
Brain Neoplasms
APOPTOSIS
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
Phenotype
CD4 Antigens
human leucocyte antigens (HLA)
Lymphoma
Large B-Cell
Diffuse
Lymphoma
B-Cell
CD8 Antigens
lymphoma
Human leukocyte antigen
Biology
testis
Pathology and Forensic Medicine
central nervous system (CNS)
Immune system
Lymphocytes
Tumor-Infiltrating
Antigen
Testicular Neoplasms
Stomach Neoplasms
medicine
Humans
Lymphocyte Count
NON-HODGKINS-LYMPHOMA
GRANZYME-B
B cell
Tumor-infiltrating lymphocytes
MUTATIONS
Histocompatibility Antigens Class I
CENTRAL-NERVOUS-SYSTEM
Histocompatibility Antigens Class II
T lymphocyte
FAS
medicine.disease
Lymphoma
Immunology
IMMUNOGLOBULIN
CD4(+)
T-Lymphocytes
Cytotoxic
Zdroj: JOURNAL OF PATHOLOGY, 206(3), 328-336. Wiley
Riemersma, S A, Oudejans, J J, Vonk, M J, Dreef, E J, Prins, F A, Jansen, P M, Vermeer, M H, Blok, P, Kibbelaar, RE, Muris, J J F, Schuuring, E M & Kluin, P M 2005, ' High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis ', Journal of Pathology, vol. 206, no. 3, pp. 328-336 . https://doi.org/10.1002/path.1783
Journal of Pathology, 206(3), 328-336. John Wiley and Sons Ltd
ISSN: 0022-3417
DOI: 10.1002/path.1783
Popis: Loss of both HLA class I and class 11 expression in B cell lymphomas is a mechanism of escape from a cytotoxic T lymphocyte (CTL) immune response and will therefore give a strong selective survival advantage in tumours expressing strong immunogenic antigens. We investigated loss of HLA expression using specific antibodies on tissue sections from 254 B cell lymphomas originating from nodal and different extranodal sites in relation to numbers of tumour-infiltrating T cells. Complete loss of HLA class I and 11 was observed in a minority of the nodal, stomach, and skin lymphomas but in the majority of the lymphomas originating from the testis and the CNS. Interestingly, relatively high percentages of activated CTLs were detected in both primary testicular and CNS lymphomas compared to lymphomas at other sites, with highest percentages in the testis (p
Databáze: OpenAIRE
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