Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
| Autor: | Deborah M. Lambert, Ciara Dolan, John T. O'Brien, Eileen P. Treacy, Eoin O'Brien, Alice Stanton, Denis C. Shields |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
lcsh:Internal medicine Genotype lcsh:QH426-470 Population Mutation Missense Physiology Disease Biology Essential hypertension White People Methylamines Risk Factors Genetics medicine Missense mutation Humans Genetics(clinical) Genetic Predisposition to Disease education lcsh:RC31-1245 Genetics (clinical) Aged Aged 80 and over education.field_of_study Polymorphism Genetic Haplotype Case-control study Middle Aged medicine.disease lcsh:Genetics Blood pressure Haplotypes Cardiovascular Diseases Case-Control Studies Hypertension Oxygenases Metabolism Inborn Errors Research Article |
| Zdroj: | BMC Medical Genetics, Vol 6, Iss 1, p 41 (2005) BMC Medical Genetics |
| ISSN: | 1471-2350 |
| Popis: | Background The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension. Methods FMO3 genotypes (E158K, V257M, E308G) were determined in 387 healthy subjects with ambulatory systolic and diastolic blood pressure measurements, and in a cardiovascular disease population of 1649 individuals, 691(41.9%) of whom had a history of hypertension requiring drug treatment. Haplotypes were determined and their distribution noted. Results There was no statistically significant association found between any of the 4 common haplotypes and daytime systolic blood pressure in the healthy population (p = 0.65). Neither was a statistically significant association found between the 4 common haplotypes and hypertension status among the cardiovascular disease patients (p = 0.80). Conclusion These results suggest that the variants in the FMO3 gene do not predispose to essential hypertension in this population. |
| Databáze: | OpenAIRE |
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