Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study

Autor: Frank Dellanna, Gérard M. London, Philippe Zaoui, Johannes F.E. Mann, Christian Combe, Andriy Krendyukov, Karen MacDonald, Kris Denhaerynck, David Goldsmith, Ivo Abraham
Přispěvatelé: Bioingénierie tissulaire (BIOTIS), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Guy's and St Thomas' NHS Foundation Hospital [Londres, Royaume-Uni], DaVita Clinical Research [Düsseldorf, Allemagne], Université de Grenoble, Centre Hospitalier Manhès [Fleury-Mérogis], Matrix45 [Tucson, Arizona], Department of Public Health [Basel, Suisse], University of Basel (Unibas), Hexal AG [Holzkirchen, Allemagne], College of Pharmacy and College of Medicine [Tucson, Arizona], University of Arizona, The MONITOR-CKD5 study was funded by Hexal AG., Bodescot, Myriam, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_treatment
030232 urology & nephrology
030204 cardiovascular system & hematology
lcsh:RC870-923
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
0302 clinical medicine
Medizinische Fakultät
Medicine
Prospective Studies
Aged
80 and over
education.field_of_study
Dialysis adequacy
Life-years
Middle Aged
Optimal management
3. Good health
Europe
Haemodialysis
Treatment Outcome
Nephrology
Life years gained
Female
Quality-Adjusted Life Years
medicine.symptom
Modifiable haemodialysis practices
Research Article
Adult
medicine.medical_specialty
Biosimilar epoetin alfa
Population
Vascular access
Anaemia
03 medical and health sciences
Young Adult
Renal Dialysis
Internal medicine
Environmental health
Humans
ddc:610
Renal Insufficiency
Chronic
education
Dialysis
Aged
business.industry
Relative mortality
lcsh:Diseases of the genitourinary system. Urology
[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
business
Weight gain
Zdroj: BMC Nephrology
BMC Nephrology, BioMed Central, 2019, 20 (1), pp.81. ⟨10.1186/s12882-019-1251-z⟩
BMC Nephrology, Vol 20, Iss 1, Pp 1-12 (2019)
ISSN: 1471-2369
Popis: Background DOPPS reported that thousands of life-years could be gained in the US and Europe over 5 years by correcting six modifiable haemodialysis practices. We estimated potential life-years gained across 10 European countries using MONITOR-CKD5 study data. Methods The DOPPS-based target ranges were used, except for haemoglobin due to label changes, as well as DOPPS-derived relative mortality risks. Percentages of MONITOR-CKD5 patients outside targets were calculated. Consistent with the DOPPS-based analyses, we extrapolated life-years gained for the MONITOR-CKD5 population over 5 years if all patients were within targets. Results Bringing the 10 MONITOR-CKD5 countries’ dialysis populations into compliance on the six practices results in a 5-year gain of 97,428 patient-years. In descending order, survival impact was the highest for albumin levels, followed by phosphate levels, vascular access, haemoglobin, dialysis adequacy, and interdialytic weight gain. Conclusions Optimal management of the six modifiable haemodialysis practices may achieve 6.2% increase in 5-year survival. Trial Registration NCT01121237. Clinicaltrials.gov registration May 12, 2010 (retrospectively registered). Electronic supplementary material The online version of this article (10.1186/s12882-019-1251-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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