Wireless Passive Stimulation of Engineered Cardiac Tissues
| Autor: | Xueling Meng, Shiyi Liu, Junseok Chae, Mehdi Nikkhah, Ali Navaei |
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| Rok vydání: | 2017 |
| Předmět: |
Fluid Flow and Transfer Processes
Materials science Pulse (signal processing) Process Chemistry and Technology 020208 electrical & electronic engineering Transistor Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology law.invention law 0202 electrical engineering electronic engineering information engineering Waveform Radio frequency Antenna (radio) 0210 nano-technology Instrumentation Microwave Biomedical engineering Voltage Diode |
| Zdroj: | ACS Sensors. 2:1006-1012 |
| ISSN: | 2379-3694 |
| Popis: | We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm3 on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca2+ transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5–2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions. |
| Databáze: | OpenAIRE |
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