Modified Method for Detection of Benzoylecgonine in Human Urine by GC-MS: Derivatization Using Pentafluoropropanol/Acetic Anhydride
| Autor: | William E. Bronner, Kasandra M. Paulemon, Zachary J. Fuller, Michelle C. Serafin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Health
Toxicology and Mutagenesis Acetic Anhydrides Modified method 02 engineering and technology Urine Toxicology 01 natural sciences Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Cocaine Environmental Chemistry Humans Derivatization Fluorocarbons Chemical Health and Safety Chromatography Illicit Drugs 010401 analytical chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Reaction product Substance Abuse Detection Acetic anhydride chemistry Reagent Benzoylecgonine Gas chromatography–mass spectrometry 0210 nano-technology |
| Zdroj: | Journal of analytical toxicology. 41(4) |
| ISSN: | 1945-2403 |
| Popis: | An existing GC-MS method for detecting benzoylecgonine (BZE) in urine was modified by changing derivatizing reagents. This method modification presents a cost-effective alternative derivatization procedure for the detection of BZE in urine by GC-MS. The combination of pentafluoropropanol and acetic anhydride was found to produce the same reaction product for BZE as pentafluoropropanol with pentafluoropropionic anhydride, while reducing reagent cost. With no anhydride present, derivatization of BZE by pentafluoropropanol did not occur. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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