The murine allantois: emerging paradigms in development of the mammalian umbilical cord and its relation to the fetus
| Autor: | Karen M. Downs, Kimberly E. Inman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Neovascularization
Physiologic Gestational Age Biology Umbilical cord Umbilical Cord Fetal Development Mice Endocrinology Allantois Pregnancy Placenta Genetics medicine Conceptus Animals reproductive and urinary physiology Embryonic Stem Cells Fetus Primitive streak Embryo Cell Biology Anatomy Chorion Embryonic stem cell Cell biology Hematopoiesis medicine.anatomical_structure Germ Cells embryonic structures Mutation Female |
| Zdroj: | Genesis (New York, N.Y. : 2000). 45(5) |
| ISSN: | 1526-954X |
| Popis: | The fertilized egg of the mammal gives rise to the embryo and its extraembryonic structures, all of which develop in intimate relation with each other. Yet, whilst the past several decades have witnessed a vast number of studies on the embryonic component of the conceptus, study of the extraembryonic tissues and their relation to the fetus have been largely ignored. The allantois, precursor tissue of the mature umbilical cord, is a universal feature of all placental mammals that establishes the vital vascular bridge between the fetus and its mother. The allantois differentiates into the umbilical blood vessels, which become secured onto the chorionic component of the placenta at one end and onto the fetus at the other. In this way, fetal blood is channeled through the umbilical cord for exchange with the mother. Despite the importance of this vascular bridge, little is known about how it is made. The aim of this review is to address current understanding of the biology of the allantois in the mouse and genetic control of its features and functions, and to highlight new paradigms concerning the developmental relationship between the fetus and its umbilical cord. genesis 45: 237–258, 2007. Published 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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