Heterogeneity of Fractional Anisotropy and Mean Diffusivity Measurements by In Vivo Diffusion Tensor Imaging in Normal Human Hearts
| Autor: | Panfilov, AV, McGill, L-A, Scott, AD, Ferreira, PF, Nielles-Vallespin, S, Ismail, T, Kilner, PJ, Gatehouse, PD, de Silva, R, Prasad, SK, Giannakidis, A, Firmin, DN, Pennell, DJ |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Materials science Heart Diseases lcsh:Medicine CARDIAC FIBER ARCHITECTURE Thermal diffusivity MUSCLE CELL DISORGANIZATION Sensitivity and Specificity Young Adult Nuclear magnetic resonance In vivo Fractional anisotropy medicine LAMINAR STRUCTURE Humans Water diffusion Anisotropy lcsh:Science MYOCARDIAL MICROSTRUCTURE Multidisciplinary Science & Technology HISTOLOGICAL VALIDATION medicine.diagnostic_test HYPERTROPHIC CARDIOMYOPATHY lcsh:R Reproducibility of Results Magnetic resonance imaging Heart Anatomy Middle Aged QUANTITATIVE-ANALYSIS WATER DIFFUSION Healthy Volunteers Multidisciplinary Sciences Normal variation Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging CARDIOVASCULAR MAGNETIC-RESONANCE Science & Technology - Other Topics CANINE LEFT-VENTRICLE lcsh:Q Female Diffusion MRI Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 7, p e0132360 (2015) |
| ISSN: | 1932-6203 |
| Popis: | Background: Cardiac diffusion tensor imaging (cDTI) by cardiovascular magnetic resonance has the potential to assess microstructural changes through measures of fractional anisotropy (FA) and mean diffusivity (MD). However, normal variation in regional and transmural FA and MD is not well described.\ud \ud Methods: Twenty normal subjects were scanned using an optimised cDTI sequence at 3T in systole. FA and MD were quantified in 3 transmural layers and 4 regional myocardial walls.\ud \ud \ud Results: FA was higher in the mesocardium (0.46 ±0.04) than the endocardium (0.40 ±0.04, p≤0.001) and epicardium (0.39 ±0.04, p≤0.001). On regional analysis, the FA in the septum was greater than the lateral wall (0.44 ±0.03 vs 0.40 ±0.05 p = 0.04). There was a transmural gradient in MD increasing towards the endocardium (epicardium 0.87 ±0.07 vs endocardium 0.91 ±0.08×10-3 mm2/s, p = 0.04). With the lateral wall (0.87 ± 0.08×10-3 mm2/s) as the reference, the MD was higher in the anterior wall (0.92 ±0.08×10-3 mm2/s, p = 0.016) and septum (0.92 ±0.07×10-3 mm2/s, p = 0.028). Transmurally the signal to noise ratio (SNR) was greatest in the mesocardium (14.5 ±2.5 vs endocardium 13.1 ±2.2, p |
| Databáze: | OpenAIRE |
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