Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly
| Autor: | Charleen Zoumalan, Erin Siu, Jeffrey L. Cummings, Gary W. Small, Liana G. Apostolova, Steve Rogers, Arthur W. Toga, Amity E. Green, Paul M. Thompson, Calen A. Steiner, Michael E. Phelps, Daniel H.S. Silverman, Ivo D. Dinov |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research Cognitive decline Brain mapping 0302 clinical medicine Cognition Medicine & Public Health Medicine Mild cognitive impairment (MCI) skin and connective tissue diseases Aged 80 and over Medicine(all) Brain Mapping medicine.diagnostic_test Imaging / Radiology 05 social sciences Brain Middle Aged humanities Oncology Feature (computer vision) Positron emission tomography Medicine public health Positron emission tomography (PET) Alzheimer's disease (AD) Cardiology Female Research Article medicine.medical_specialty Surface Properties 050105 experimental psychology 03 medical and health sciences Fluorodeoxyglucose F18 Internal medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Psychiatry Aged Demography Extramural business.industry Longitudinal positron emission tomography social sciences medicine.disease Positron-Emission Tomography sense organs business Cognition Disorders 030217 neurology & neurosurgery |
| Zdroj: | Apostolova, Liana G.; Thompson, Paul M.; Rogers, Steve A.; Dinov, Ivo D.; Zoumalan, Charleen; Steiner, Calen A.; et al.(2010). Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly. Molecular Imaging and Biology, 12(2), pp 218-224. doi: 10.1007/s11307-009-0247-7. Retrieved from: http://www.escholarship.org/uc/item/5t88j4s3 Molecular Imaging and Biology |
| DOI: | 10.1007/s11307-009-0247-7. |
| Popis: | Purpose The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 ± 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-PET scan (interval 21.7 ± 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Results Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10–15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5–5% similarly distributed decline. ApoE4-positive individuals underwent 5–15% metabolic decline in the posterior association cortices. Conclusions Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group. |
| Databáze: | OpenAIRE |
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